FEATURES OF THE MICROBIAL PICTURE, THE ACTIVITY OF THE PHAGOCYTOSIS SYSTEM AND THE PROFILE OF KEY CYTOKINES IN PATIENTS WITH RHINOSINUSITES AND OTITIS MEDIA CAUSED BY THE TYPE 2 DIABETES 

Baranova Nadezhda Ivanovna, Doctor of biological sciences, professor, sub-department of immunology and allergology, head of the Central Research Laboratory, Penza Institute of Advanced Medical Studies – branch of the Federal State Government-financed Educational Establishment of Additional Professional Education “Russian Medical Academy of Life-long Professional Learning” of the Ministry of Healthcare of the Russian Federation (8A Stasova street, Penza, Russia), E-mail: baranova.nadezhda.2014@mail.ru
Shkurova Natal'ya Aleksandrovna, Assistant, sub-department of otorhinolaryngology and audiology-otorhinolaryngology, Penza Institute of Advanced Medical Studies – branch of the Federal State Government-financed Educational Establishment of Additional Professional Education “Russian Medical Academy of Life-long Professional Learning” of the Ministry of Healthcare of the Russian Federation (8A Stasova street, Penza, Russia), E-mail: Lor-dr@mail.ru
Fedin Andrey Viktorovich, Associate professor, sub-department of otorhinolaryngology and audiologyotorhinolaryngology, Penza Institute of Advanced Medical Studies – branch of the Federal State Government-financed Educational Establishment of Additional Professional Education “Russian Medical Academy of Life-long Professional Learning” of the Ministry of Healthcare of the Russian Federation (8A Stasova street, Penza, Russia), E-mail: saintmartyn@yandex.ru 

616.216-002+.28-002 

10.21685/2072-3032-2020-2-1 

Background. The main purpose of this work is to study features of the microbial picture, the activity of the phagocytosis system and the profile of key cytokines in patients with rhinosinusites and otitis media caused by the type 2 diabetes.
Materials and methods. 110 patients were examined. 76 patients had rhinosinusitis and otitis media followed by type 2 diabetes (group 1) and 34 patients had only rhinosinusitis and otitis media (group 2).
Results. In microbiological study Staphylococcus epidermidis (23.6 %), Staphylococcus aureus (19,7 %), Pseudomonas aeruginosa (9,2 %) were the most pathogen in patients group 1. The decreases of PCC-test, the decrease of IL-1 level, the increase of IL-10 were identified in patients group 1 in comparison with patients group 2.
Conclusions. The decrease of functional indicators according to PCC-test in patients group 1 compared with patients group 2 demonstrates “the lack of reserve of neutrophils activation”. The increase IL-10 proves the activation of regulatory T-cells. 

rhinosinusitis, otitis media, type 2 diabetes, immunity 

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